Development and Validation of RP-HPLC Method for Estimation of Vortioxetine in Bulk and Pharmaceutical Dosage Form

Bargaje G. S; Rathod G. R | Deshpande O. V; Rathod K. G

Title:
Development and Validation of RP-HPLC Method for Estimation of Vortioxetine in Bulk and Pharmaceutical Dosage Form

Authors:
Rathod K. G | Bargaje G. S | Rathod G. R | Deshpande O. V

Cite This Article :

Rathod K. G | Bargaje G. S | Rathod G. R | Deshpande O. V "Development and Validation of RP-HPLC Method for Estimation of Vortioxetine in Bulk and Pharmaceutical Dosage Form" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-6, October 2019, pp.74-88, URL: https://www.ijtsrd.com/papers/ijtsrd28040.pdf

Download

Abstract :
A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Vortioxetine in its pure form as well as in tablet dosage form. Chromatography was carried out on ODS C18 (4.6 x 250 mm, 5µm) column using Acetonitrile And Methonal (70:30) as the mobile phase at a flow rate of 1.0 mL/min, the detection was carried out at 274nm. The retention time of the Vortioxetine was 2.922 ±0.02min. The method produce linear responses in the concentration range of 20 µg/ml of Vortioxetine. The method precision for the determination of assay was below 2.0 %RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.

Keywords :
Vortioxetine; RP-HPLC; PDA Detection; validation; Tablet dosage forms

Publication Details:

Unique Identification Number : IJTSRD28040

Published In : Volume-3 | Issue-6, October 2019

Page Number(s) : 74-88

Publisher Name : IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470

Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

About IJTSRD
Indexing

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.